COVID19 Vaccines, How are they going?

Around the world, on July 27, it was reported more than

165

vaccines against the coronavirus

Approved: 1

In Phase III: 5

Difference between Preclinical, Phase I, Phase II, Phase III, and Approval

PreclinicalPhase IPhase IIPhase IIIApproval
Assay in animals as mice or monkeysSmall number of peopleHundreds of people, different ages.
Needs to protect at least 50% of vaccinated people
Thousands of people, compared with people who received placebo.Regulators in each country decide whether to approve the vaccine or not
140+191251

Phase III:

InstitutionSponsorCandidatePhase III conducted in
Murdoch Children’s Research InstituteUniversity of Melbourne Bacillus Calmette Guerin (BCG)Australia, Spain, and Netherlands
Sinovac BiotechSinovac Research and Development Co. LtdCoronavacBrazil
Wuhan Institute of Biological ProductsMinistry of Science and TechnologyInactivated vaccineUnited Arab Emirates
The University of OxfordAstraZeneca, IQVIAAZD1222England, Brazil, South Africa
National Institutes of HealthModernamRna-1273Will start by Operation Warp Speed

Approved: CanSino BIO

The Chinese CanSino Biologics developed this vaccine based on the adenovirus type 5 vector (Ad5). Adverse reactions as pain (54%), fever (46%), fatigue (44%) headache (39%), and muscle pain (17%) occurred in 83% of patients in the low and medium dose groups and 75% of patients in the high dose group. On 25 June, China’s Central Military commission announced the military had been approved to use Ad5-nCoV for a period of 1 year.

Important Companies in Phase I, II

References